Electric Literature of 20781-06-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 20781-06-0, name is 2,4-Diaminopyrimidine-5-carboxaldehyde. A new synthetic method of this compound is introduced below.
A mixture of 0.188 g (1 mmol) of compound of formula V and 0.447 g (1.5 mmol) of compound of formula III-1, 0.126 g (2 mmol) of sodium cyanoborohydride was added and maintained in a reflux state for 24 hours in 15 mL of methanol, The water was washed with ethyl acetate and the organic phase was washed with saturated brine and the organic phase was concentrated (the solvent was removed under reduced pressure). The residue was purified by silica gel column chromatography (Eluent: methanol: dichloromethane = 1: 10, v / v) to give a white solid (IB-1) The yield was 78%
At the same time, in my other blogs, there are other synthetic methods of this type of compound,20781-06-0, 2,4-Diaminopyrimidine-5-carboxaldehyde, and friends who are interested can also refer to it.
Reference:
Patent; East China University of Science and Technology; Zhu Jin; Huang Jin; Chen Wenhua; Yao Xue; Ling Dazheng; Wang Manjiong; Jiang Hualiang; Li Jian; (21 pag.)CN106938997; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia