Application of 1004-39-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1004-39-3 as follows.
To a flask equipped with a magnetic stirrer added 4,6-diamino-2-mercaptopyrimidine (1.4218g, 0.01mmol). It was dissolved in 40mL of methanol and added 42mL 0.25M aqueous sodium hydroxide solution. The above aqueous solution was added to the flask and stirred for 2.5 hours at room temperature to give the sodium salt of a mercapto group. After completion of the reaction, Vacuum distillation and Vacuum drying was used overnight. The dried Mercapto sodium salt was dissolved in 62mL of N, N- dimethylformamide (DMF) and Added in Step 2) obtained 4′-(1-bromo-4-butoxy)-4-cyanoazobenzene (3.9820g, 0.11mmol), stirred at room temperature for 20h. After completion of the reaction, ethyl acetate was added then dried overnight over anhydrous magnesium sulfate, filtered, Rotary evaporated to remove residual solvent. The crude product was further purified by silica gel column chromatography and finally get a diamine containing Azo-Pyrimidine monomer
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1004-39-3, its application will become more common.
Reference:
Patent; Yidun New Materials (Suzhou) Co., Ltd.; Lu, Qinghua; Tong, Faqin; (24 pag.)CN105693625; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia