Synthetic Route of 705263-10-1 ,Some common heterocyclic compound, 705263-10-1, molecular formula is C6H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
The mixture of 15a (0.87 g, 4.39 mmol), 4-[4-(tert- butoxycarbonyl)piperazin-l-yl]phenylboronic acid pinacol ester (1.7 g, 4.39 mmol), Pd(Ph3P)4 (0.5 g, 0.439 mmol), K2CO3 (1.82 g, 13.17), 1 ,4-dioxane (15 mL) and H2O (5 mL) was heated at 1 10 C under a nitrogen atmosphere for 5 h in a sealed vial. The reaction mixture was concentrated and the residue was purified by column chromatography using CH2Cl2/EtOAc to give 16 (1.4 g, 86% yield). 1H NMR (CDCl3) delta 8.82 (dd, J = 2.2, 0.7 Hz, IH), 8.77 (d, J = 2.2 Hz, I H), 8.16 (d, J = 2.2 Hz, 1 H), 7.54 (d, J = 8.8 Hz, 2H), 7.08 (d, J = 8.8 Hz, 2H), 6.75 (dd, J = 2.2, 0.7 Hz, 1 H), 3.63 – 3.67 (m, 4H), 3.25 – 3.28 (m, 4H), 1.53 (s, 9H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 705263-10-1, 6-Bromopyrazolo[1,5-a]pyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE GENERAL HOSPITAL CORPORATION; THE BRIGHAM AND WOMEN’S HOSPITAL, INC.; WO2009/114180; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia