Electric Literature of 88474-31-1 ,Some common heterocyclic compound, 88474-31-1, molecular formula is C6H8ClN3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
5-amino-4-methoxy-6-chloro-3-methyl-pyrimidine (2.0grams, 11.5mmol) and N-acetylimidazolidinone (2.0 grams, 11,5mmol) were dissolved in anhydrous DMSO and anhydrous sodium carbonate (3.75 grams, 35.4mmol, 2.0 equivalents) was added. The reaction flask was cooled in ice-salt-acetone mixture and POCl3 was added dropwise in 1 hour keeping temperature below 5C. After the addition the ice bath was removed and the flask was stirred at 58-60C under nitrogen for 2 days. A small sample was taken and analysed by HPLC. There was no starting material and the product was formed. The anhydrous Na2CO3 neutralized the HCl gas in situ as it formed. Workup: The reaction mixture was quenched by slowly pouring in crushed ice. The product precipitated and the product was filtered and dried under vacuum. Without any further purification the product was used in the next step to generate crude moxonidine. Yield: 2.64 grams. Mass spec.: 283 (m+)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 88474-31-1, 4-Chloro-6-methoxy-2-methylpyrimidin-5-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Abbott Healthcare Products B.V.; ABBOTT LABORATORIES; ACQUASALIENTE, Maurizio; LAGERWEIJ, Gert; DESHPANDE, Mahendra; SHAH, Rajendra; EP2829540; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia