Adding a certain compound to certain chemical reactions, such as: 56844-40-7, 6-Bromothieno[2,3-d]pyrimidin-4(3H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines
1 L cc. sulfuric acid was cooled with ice-water bath and 72.0 g potassium iodide (0.434mol) was added in portions during 15 minutes and then 32.4 g sodium periodate (0.151mol) during a 10 minutes period. The resulting mixture was stirred at room temperature for30 minutes then 80.0 g 6-bromo-3H-thieno[2,3-djpyrimidin-4-one (0.346 mol) was addedto the mixture in portions in 30 minutes while the internal temperature was kept between -21 C and -19 C. The reaction mixture was stirred at -20 C for 1,5 hours. lee (3 kg) was added to the suspension then the precipitate was filtered off, washed with water (3×500 mL), finally with diethyl ether (3×200 mL) and air dried to give the product as a tan crystalline solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,56844-40-7, 6-Bromothieno[2,3-d]pyrimidin-4(3H)-one, and friends who are interested can also refer to it.
Reference:
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LIMITED; KOTSCHY, Andras; SZLAVIK, Zoltan; CSEKEI, Marton; PACZAL, Attila; SZABO, Zoltan; SIPOS, Szabolcs; RADICS, Gabor; PROSZENYAK, Agnes; BALINT, Balazs; BRUNO, Alain; GENESTE, Olivier; DAVIDSON, James Edward Paul; MURRAY, James Brooke; CHEN, I-Jen; PERRON-SIERRA, Francoise; WO2015/97123; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia