Application of 22536-65-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.22536-65-8, name is 2-Chloro-5-methoxypyrimidine, molecular formula is C5H5ClN2O, molecular weight is 144.56, as common compound, the synthetic route is as follows.
2-chloro-5-methoxypyrimidine (0.150 g, 1.038 mmol) was added to a 50 mL round bottom flask.Norfloxacin(0.331g, 1.038mmol)And potassium carbonate (0 · 172g, 1 · 246mmol), then add 10mL acetonitrile,Reflow at 80 ° Ctwenty fourhour.After the reaction,The reaction mixture was concentrated under reduced pressure to give a crude material.Then use the eluent (methanol / dichloromethane,1/10, V/V)Purified by silica gel column chromatography,0.215 g of compound 1-4 were obtained,It is a yellow solid. Yield: 50.3percent
Statistics shows that 22536-65-8 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-5-methoxypyrimidine.
Reference:
Patent; Southwest University; Zhou Chenghe; Li Di; Chen Jinping; Ba Tini·nasaiya; An Sali·muhanmode·fuade; (19 pag.)CN109942546; (2019); A;,
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