In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 425394-89-4, name is 4,6-Dichloropyrimidin-5-ol, the common compound, a new synthetic route is introduced below. HPLC of Formula: C4H2Cl2N2O
(1) 5-(Benzyloxy)-4,6-dichloropyrimidine, INT 45 To a solution of INT 37 (content 90%, 6.50 g, 35.50 mmol) in DMF (120 mL) was added benzyl bromide (8.42 mL, 70.90 mmol) followed by potassium carbonate (14.70 g, 106.36 mmol). The reaction mixture was stirred at 60 C. for 1 hr. The mixture was concentrated. The residue was partitioned between EtOAc and water. The organic layer was washed with water and brine, dried over magnesium sulfate, filtered and concentrated. The residue was purified by flash chromatography (silica; cyclohexane/EtOAc gradient, 0-10%) to afford INT 45 as a colorless oil. UPLC-MS: MS (ESI): [M+H]+ 255.1, rt=1.15 min. 1H NMR (DMSO-d6): delta (ppm) 8.72 (s, 1H), 7.57-7.50 (m, 2H), 7.48-7.37 (m, 3H), 5.19 (s, 2H).
The synthetic route of 425394-89-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; ANGST, Daniela; GESSIER, Francois; VULPETTI, Anna; US2015/152068; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia