Electric Literature of 1114560-76-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1114560-76-7, name is 4-Bromo-2-methylpyrimidine. A new synthetic method of this compound is introduced below.
Example 46a 6-Methoxy-5-(2-methyl-pyrimidin-4-yl)-pyridin-2-ylamine PdCl2(PPh3)2 (413 mg, 0.58 mmol) was added to a degassed mixture of 4-bromo-2-methyl-pyrimidine (1.02 g, 5.89 mmol), 6-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-ylamine 2 (Example 7c, 2.2 g, 8.79 mmol) and K2CO3 (2.43 g, 17.6 mmol) in a mixture of DME, EtOH and H2O (6:2:1, 200 mL). The reaction mixture was heated in a sealed tube for 1 hour at 100 C. The mixture was cooled to room temperature, diluted with ethyl acetate and filtered. The volatiles were removed in vacuo and the residue was purified by flash column chromatography using a gradient of 5 to 10% EtOAc in DCM to afford 610 mg (48%) of the title compound. 1H NMR (400 MHz, CD3OD) delta ppm 2.74 (s, 3H) 4.06 (s, 3H) 6.29 (d, 1H) 8.27 (d, 1H) 8.45 (d, 1H) 8.55 (d, 1H). ESMS m/z 217.0 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1114560-76-7, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; US2012/122843; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia