Electric Literature of 13162-26-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 13162-26-0 as follows.
Cyclopentylamine(5.2ml) and N,N-diisopropylethylamine(13.2ml) were dissolved into 150ml dichloromethane. The mixture was added dropwise to a solution of 2,4-dichloro-5-nitro-6-methylpyrimidine(10.7g) in dichloromethane(30ml) at 0C. After the completion of the dropwise addition, the mixture was kept at the same temperature to react for 1 hour. Purification was conducted by a column chromatography to obtain a bright-yellow solid(11.2g) in a yield of 84.8%. 1H NMR(400 MHz, CDCl3): delta 8.44(s, 2H), 4.41(m, 1H), 2.64(s,3H), 2.01-2.15(m, 2H), 1.61-1.76(m, 4H), 1.45-1.63(m, 2H)ppm.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13162-26-0, its application will become more common.
Reference:
Patent; Si Chuan University; CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; YANG, Shengyong; WEI, Yuquan; EP2578584; (2013); A1;,
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