In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17321-93-6, name is 2-Amino-5-bromo-4-methylpyrimidine, the common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Amino-5-bromo-4-methylpyrimidine
Intermediate G 4-Methyl-5-(4,4,5,5-tetramethyl-[l,3,2]dioxoborolan-2-yl]-pyrimidin-2-ylamine; Palladium II dichloride (0.189 g, 1.06 mmol) is added to a solution of [1,1- bis(diphenylphosphino)ferrocene] (0.608 g, 1.06 mmol) in degassed dimethylformamide (20 ml) and the mixture is stirred at 50° C for 15 min. After cooling to room temperature 5-bromo-4-methylpyrimidine-2-ylamine (1.0 g, 5.32 mmol), bis-(4,4,5,5-tetramethyl- [l,3]dioxolan-2-yl]-borane (1.65 g, 6.38 mmol) and potassium acetate (1.57 g , 16 mmol) are added. The mixture is heated at 95° C for 16 hours then the solvent is removed under reduced pressure. The crude mixture is suspended in DCM (250 ml) and filtered through a pad of Celite.(R). (filter agent), the filtrate was washed with water (20 ml), dried over MgSO4 and evaporated to dryness. Purification by flash chromatography on silica using cyclohexane/ ethyl acetate (4 : 1) mixture provides the title compound.
The synthetic route of 17321-93-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; WO2009/13348; (2009); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia