Synthetic Route of 60025-09-4 ,Some common heterocyclic compound, 60025-09-4, molecular formula is C5H3ClN4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
S)-2-(1 -Aminoethyl)-5-((2-hydroxyphenyl)thio)-3-phenylpyrrolo[2,1 -f|[1 ,2,4]triazin- 4(3H)-one (183 mg, 0.36 mmol) was treated with 4-amino-6-chloropyrimidine-5- carbonitrile (84 mg, 0.54 mmol), and Lambda/,/V-diisopropylethylamine (380 muIota, 2.18 mmol) in ie f-butanol according to the method described in Example 17. The crude was purified by reverse phase using SP1Purification System to give 69 mg (38% yield) of the title compound as a white solid. Purity 100%.LRMS (m/z): 497 (M+1 )+1H NMR (400 MHz, DMSO-d6) delta 9.84 (s, 1 H), 7.78 (s, 1 H), 7.66 (t, J = 4.8 Hz, 2H), 7.49 (d, J = 8.0 Hz, 1 H), 7.46 – 7.38 (m, 1 H), 7.37 – 7.26 (m, 3H), 7.20 (s, 2H), 7.15 – 7.03 (m, 2H), 6.88 (dd, J = 8.0, 1.0 Hz, 1 H), 6.80 – 6.71 (m, 1 H), 6.25 (d, J = 2.8 Hz, 1 H), 4.88 (p, J = 6.6 Hz, 1 H), 1 .36 (d, J = 6.6 Hz, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60025-09-4, its application will become more common.
Reference:
Patent; ALMIRALL, S.A.; ERRA SOLA, Montserrat; CARRASCAL RIERA, Marta; TALTAVULL MOLL, Joan; CATURLA JAVALOYES, Juan Francisco; BERNAL ANCHUELA, Francisco Javier; PAGES SANTACANA, Lluis Miquel; MIR CEPEDA, Marta; CASALS COLL, Gaspar; HERNANDEZ OLASAGARRE, Maria Begona; WO2014/60432; (2014); A1;,
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