In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 137281-39-1, name is 4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid, the common compound, a new synthetic route is introduced below. Recommanded Product: 137281-39-1
Weigh 4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid (60 g 0.2 mol) Add to a 500ml four-neck bottle,Add 200ml of DMF and 40.4g of triethylamine to the temperature to 30 C and stir to dissolve.Trityl chloride (0.3 mol) was added dropwise, the reaction was kept at 35 C for 1 hour, and DMF was evaporated to dryness under reduced pressure.Add 200ml of pure water to stir, adjust the pH to 5-6 with dilute hydrochloric acid, stir the crystal, cool down to 0-5 C, filter and dry the product.4-[2-(2-triphenylmethylamino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid (molar yield) 96.3%, purity 99.1%).
The synthetic route of 137281-39-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Lunan Pharmaceutical Group Co., Ltd.; Xia Mingjun; Zang Chao; (11 pag.)CN110305137; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
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