Application of 257280-25-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 257280-25-4, name is 5-Bromo-2-phenoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
5-Bromo-2-phenoxypyrimidine (Formula 12-2, 412 mg, 1.64 mmol) synthesized in Step 1 was dissolved in THF (10 ml), cooled to -78 C, and 1.6M n-butyl Lithium (1.85 ml, 2.95 mmol, 1.8 eq) was added dropwise. Then, after stirring for 1 hour at the same temperature, triisopropylborate (0.762 ml, 3.28 mmol, 2 eq) was added dropwise at the same temperature. The reaction mixture was stirred at the same temperature for 1 hour, then raised to 0 C. and 4.5M aqueous potassium hydrogendifluoride solution (1.1 ml, 4.92 mmol, 3 eq) was added dropwise. The reaction mixture was stirred at room temperature for 1 hour. After completion of the reaction, the solvent was removed under reduced pressure. Thereafter, the reaction mixture was dissolved in methanol and filtered, and the filtrate was reduced under reduced pressure to obtain a target compound (Formula 12-3).
According to the analysis of related databases, 257280-25-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Dae Caliber Buk Peak Medical Industry Promotion Foundation; Establishment Am Center; Song Min-su; Im Chun-yeong; Park Ga-yeong; Go Eun-bi; Kang Ji-hui; Woo Seo-yeon; Kim Sung-hyeon; Hwang Hui-jong; Lee Eun-hye; Kim Hyo-ji; Kim Su-yeol; (155 pag.)KR2019/109007; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia