Adding a certain compound to certain chemical reactions, such as: 6693-08-9, 2,4,6-Trichloro-5-fluoropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 6693-08-9, blongs to pyrimidines compound. Product Details of 6693-08-9
2,4,6-trichloro-5-fluoropyrimidine (2.21 g, 8.78 mmol),(+/-)-trans-3-aminobicyclo[2.2.2]octane-2-carboxylic acid methyl ester (1.75 g, 8.78 mmol)And K2CO3 (2.43 g, 17.60 mmol) was suspended in DMF (5 mL).The resulting suspension was stirred at room temperature overnight. The reaction was quenched by the addition of H 2 O (100 mL).The resulting mixture was extracted with ethyl acetate (50 mL×3).The combined organic phases were washed with saturated brine (80 mL×3).Dry over anhydrous sodium sulfate, filter, and concentrate the filtrate under reduced pressure.The residue was purified by silica gel column chromatography (EtOAc (EtOAc)The title compound was obtained as a white solid(2.71 g, 89%).
The synthetic route of 6693-08-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Tang Changhua; Yin Junjun; Yi Kai; Lei Yibo; Wang Yejun; Zhang Yingjun; (138 pag.)CN108276401; (2018); A;,
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