Reference of 3167-50-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3167-50-8, name is 2-Aminopyrimidine-5-carboxylic acid, molecular formula is C5H5N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In a 100mL one-neck flask,2-amino-5-pyrimidinyl acid (1.39g, 10.0mmol) was dissolved in DMF (25mL), wasadded 1- (3-dimethylaminopropylAminopropyl) -3-ethylcarbodiimidehydrochloride (191mg, 1.0mmol) and triethylamine (0.42mL, 3.0mmol), stirred for10min, add1 -tert-butoxycarbonyl-piperazine (135mg,1.0mmol), the reaction at room temperature 12h. The organic solvent wasdistilled off under reduced pressure, the residue was purified by columnchromatography (twoDichloromethane / methanol (V / V) = 10/1),to give a pale yellow oil (1.25g, 56.60%).
According to the analysis of related databases, 3167-50-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; East Sunshine Pharmaceutical Co., Ltd.; Liu, Bing; Zhang, Yingjun; Nie, Linlin; Bai, Shun; Zheng, Changchun; Nie, biao; Li, Zhiyong; Tan, Yumei; (61 pag.)CN105294737; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
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