Reference of 1208170-17-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1208170-17-5, name is 4-Chloro-6-methyl-2-(methylthio)pyrimidine-5-carbonitrile, molecular formula is C7H6ClN3S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of EXAMPLE 14C (1.032 g, 5.17 mmol) in NN-dimet ylformamide (12 mL) was added EXAMPLE 14E (1.91 g, 6.2 mol) and /VN-diisopropylethylamine (1.47 g, 11.37 mmol), and the mixture was stirred at 70C for 9 hours. The cooled mixture was concentrated and the residue was dissolved in ethyl acetate, washed with water (20 mL), dried over sodium sulfate, filtered, and concentrated. The residue was purified by flash chromatography on silica gel (200~300 mesh) eluting with a gradient of 3/1 to 1/2 hexane/ethyl acetate to give the title compound. MS: 441 (M + H+).
According to the analysis of related databases, 1208170-17-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97683; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia