With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.54535-00-1, name is (5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methanol, molecular formula is C8H10N4O, molecular weight is 178.19, as common compound, the synthetic route is as follows.Recommanded Product: 54535-00-1
A slurry of 5, 7-DIMETHYL- [1, 2,4] triazolo [1,5-a] pyrimidin-2-yl)-methanol (0.3 g, 1.7 mmol) from Step 2 above and IBX (1.4 G, 5.0 mmol) in 1, 2-dichloroethane (22 mL) was stirred at 80 C for 18 hours. The reaction was cooled to room temperature, and diluted with 100 mL CH2CI2. After the solids were removed by filtration, the solvent was removed by rotary evaporation to give a yellow solid. The solid was purified by flash chromatography to give the desired product (229 mg, 77% yield). H NMR (CDCI3) 8 : 2.72 (s, 3H), 2.86 (s, 3H), 6.96 (s, 1H), 10.24 (s, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,54535-00-1, (5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; PFIZER INC.; WO2004/74270; (2004); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia