Synthetic Route of 87362-32-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 87362-32-1, name is 5-Methoxypyrimidine-2-carbonitrile, molecular formula is C6H5N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 430 5-methoxypyrimidine-2-carbonitrile (100 mg, 0.74 mmol) and Boc2O (194 mg, 0.89 mmol) and 113 MeOH (5 mL) was added to 349 Raney-Ni (30 mg, 10%), the reaction mixture was stirred at room temperature for 2 hours under a H2 atmosphere (45 psi). The reaction mixture was filtered to remove the catalyst and the filter cake was washed with MeOH (10 mL×3), and the filtrate was concentrated under vacuum. The crude product was purified by flash chromatography on silica gel (010% 56 ethyl acetate in 57 petroleum ether) to give 431 tert-butyl ((5-methoxypyrimidin-2-yl)methyl)carbamate.
According to the analysis of related databases, 87362-32-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; H. Lundbeck A/S; Juhl, Karsten; Jessing, Mikkel; Langgard, Morten; Vital, Paulo Jorge Vieira; Kehler, Jan; Rasmussen, Lars Kyhn; Clementson, Carl Martin Sebastian; Marigo, Mauro; (154 pag.)US2019/194189; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia