The origin of a common compound about 4-(4,6-Dichloropyrimidin-2-yl)morpholine

According to the analysis of related databases, 10397-13-4, the application of this compound in the production field has become more and more popular.

Reference of 10397-13-4, Adding some certain compound to certain chemical reactions, such as: 10397-13-4, name is 4-(4,6-Dichloropyrimidin-2-yl)morpholine,molecular formula is C8H9Cl2N3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10397-13-4.

A mixture of 2-difluoromethyl-lff-benzimidazole (0.168 g), 4,6-dichloro-2-morpholin- 4-yl-rhoyrimidine (0.233 g), sodium hydrogen carbonate (0.168 g) and DMA (5 ml) was stirred under nitrogen at 900C for 20 hours, filtered and evaporated. The product was purified by chromatography on silica eluting with increasing proportions of ethyl acetate in dichloromethane/iso-hexane (1:1). There was thus obtained l-(6-chloro-2-morpholin-4-yl- pyrimidin-4-yl)-2-(difluoromethyl)benzoimidazole (0.075 g); NMR Spectrum: (DMSOd6) 3.70 (m, 4H), 3.78 (m, 4H), 7.20 (s, IH), 7.39-7.72 (m, 3H), 7.84 (d, IH), 7.90 (d, IH); Mass Spectrum: M+H+ 366.

According to the analysis of related databases, 10397-13-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BUTTERWORTH, Sam; GRIFFEN, Edward, Jolyon; HILL, George, Beresford; PASS, Martin; WO2008/32036; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia