Reference of 120747-84-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.120747-84-4, name is 2-Aminopyrimidine-5-carbaldehyde, molecular formula is C5H5N3O, molecular weight is 123.11, as common compound, the synthetic route is as follows.
5G To a solution of compound 5F (0.41 g, 1.0 mmol) in CH2Cl2 (20 mL) was added a solution of compound 5G (0.31 g, 2.5 mmol, JP Patent 63227573, 1988), NaBH(OAc)3 (0.53 g, 2.5 mmol) and few drops of AcOH and the resulting reaction was allowed to stir for about 15 hours at 20 C. The reaction mixture was partitioned between 10% NaOH and CH2Cl2 and the organic layer was dried with Na2SO4 then concentrated in vacuo. The resulting residue was purified using flash chromatography (0-5% 7N NH3-CH3OH/CH2C12) to provide compound 5 (0.45g, 87%). MS: 516 (M+H).
The chemical industry reduces the impact on the environment during synthesis 120747-84-4, I believe this compound will play a more active role in future production and life.
Reference:
Patent; SCHERING CORPORATION; WO2008/108958; (2008); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia