Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 105806-13-1, name is 4,6-Dichloro-5-fluoro-2-methylpyrimidine. A new synthetic method of this compound is introduced below., Recommanded Product: 105806-13-1
Part I: (9aS)-8-(6-Chloro-5-fluoro-2-methyl-4-pyrimidinyl)octahydropyrazino[2,1 – c][1 ,4]oxazine To a mixture of (9aS)-octahydropyrazino[2,1 -c][1 ,4]oxazine dihydrochloride (23.28 g, 108.2 mmol) in DCM (360 mL) was added 4,6-dichloro-5-fluoro-2- methylpyrimidine (19.59 g, 108.2 mmol) and N,N-diisopropylethylamine (68 mL, 390.4 mmol). The mixture was stirred for 2 h, and the resulting solution was diluted with DCM (100 mL) and washed with saturated aq. NaHC03 (200 mL). The aqueous phase was extracted with a fresh portion of DCM (100 mL), and this organic phase was washed with saturated aq. NaHC03 (50 mL). The combined organic phase was dried over anhydrous Na2S04, filtered, and concentrated in vacuo to give (9aS)-8-(6-chloro-5- fluoro-2-methyl-4-pyrimidinyl)octahydropyrazino[2,1 -c][1 ,4]oxazine as a light yellow oil that was used without further purification. LCMS: (M+H)+: 287.1.
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Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED; AUBART, Kelly, Marshall; GILLIAN, Jason, Michael; QIN, Donghui; MCKEOWN, Robert, Rahn; WILLIAMS, Glenn, R.; WO2013/82388; (2013); A1;,
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