Reference of 36315-01-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 36315-01-2, name is 2-Amino-4,6-dimethoxypyrimidine. A new synthetic method of this compound is introduced below.
150 ml round-bottomed Three bottles will amine class Compound (2.0 mmol) and DMAP (2. 5 mmol) was dissolved 10 ml dichloromethane or THF or DMF, at room temperature solution containing 0.43 g 3,4-dichloro-isothiazole carboxylic acid chloride (2.0 mmol) in 2 ml of methylene chloride solution was stirred overnight at room temperature after completion , the reaction mixture was diluted with dichloromethane, washed with water, the organic layer was collected, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the product after column chromatography, eluted with a volume ratio of 10: 1 petroleum ether: 1-2 : ethyl acetate, with the resulting yield of pure calculation, depending on the yield of the amine range ranging from 16.4% to 88.7%; melting point determination of structural parameters and 1Eta NMR, etc; the chemical structure of the parameters in Table IV
At the same time, in my other blogs, there are other synthetic methods of this type of compound,36315-01-2, 2-Amino-4,6-dimethoxypyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Jiangxi Tianren Ecology Co., Ltd.; Nankai University; Chen, Xiaoyan; Liu, Xiping; Fan, Zhijin; Liang, Xiaowen; Li, Yuedong; Mao, Wutao; Li, Juanjuan; Wang, Dun; Wang, Shuhua; Zhou, Lifeng; Ji, Xiaotian; HUA, XUEWEN; (23 pag.)CN102942565; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
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