With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7043-09-6, name is 4,6-Dichloro-2-cyclopropylpyrimidine, molecular formula is C7H6Cl2N2, molecular weight is 189.04, as common compound, the synthetic route is as follows.category: pyrimidines
To a suspension of Nal (2.10 g, 13.7 mmol) in HI (55%, 10 mL) was added 4,6-dichloro-2- cyclopropylpyrimidine (2.00 g, 10.6 mmol). The resulting mixture was warmed to 40 C and stirred for 1 hour. The reaction mixture was cooled to rt and diluted with H20 (100 mL) and stirred for 15 mm. The mixture was filtered to give the title compound (2.9 g, yield 74%) as ayellow solid.1H NMR (300 MHz, CDCI3): oe 7.95 (s, 1H), 2.21-2.12 (m, 1H), 1.15-1.09 (m, 4H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,7043-09-6, 4,6-Dichloro-2-cyclopropylpyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R & D COMPANY LIMITED; DING, Xiao; JIN, Yun; LIU, Qian; REN, Feng; SANG, Yingxia; STASI, Luigi Piero; WAN, Zehong; WANG, Hailong; XING, Weiqiang; ZHAN, Yang; ZHAO, Baowei; (573 pag.)WO2017/12576; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia