As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1032452-86-0, name is 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole, molecular formula is C13H10ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole
P-toluenesulfonic acid hydrate (43.25 g) was added in one portion to 3-(2-chloropyrimidin-4-yl)-1-methyl-oxime(Intermediate 4, 32.17g)And 4-fluoro-2-cyclopropylmethoxy-5-nitroaniline (intermediate 5, 24.14g)In a mixture of 2-pentanol (500 mL).The resulting mixture was stirred at 105 C for 2.5 hours.It was then cooled to room temperature.The resulting precipitate was collected by filtration, washed with 2-pentanol (50 mL), dried under vacuum to give some of the desired product as a yellow solid.The filtrate was cooled, and the obtained precipitate was collected by filtration and washed with 2-pentanol (10 mL).The two batches were combined and triturated with CH3CN to give a solid which was collected by filtration.Drying under vacuum gave the title compound in yield86%.
With the rapid development of chemical substances, we look forward to future research findings about 1032452-86-0.
Reference:
Patent; Jiao Yuqi; (26 pag.)CN108929311; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia