A new synthetic route of 20090-69-1

Statistics shows that 20090-69-1 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-4-methylpyrimidin-5-amine.

Synthetic Route of 20090-69-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.20090-69-1, name is 2-Chloro-4-methylpyrimidin-5-amine, molecular formula is C5H6ClN3, molecular weight is 143.57, as common compound, the synthetic route is as follows.

To a solution of 2-chloro-4-methylpyrimidin-5-amine (300 mg 2.090 mmol) in THF (20 mL) was added triphosgene (620 mg 2.090 mmol) in one portion. The mixture was stirred at 60 for 20 min. LCMS analysis showed the starting material had disappeared ES-LCMS m/z 202.1 (M+MeOH)

Statistics shows that 20090-69-1 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-4-methylpyrimidin-5-amine.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R & D COMPANY LIMITED; CHEUNG, Mui; DEMARTINO, Michael P.; EIDAM, Hilary Schenck; GUAN, Huiping Amy; QIN, Donghui; WU, Chengde; GONG, Zhen; YANG, Haiying; YU, Haiyu; ZHANG, Zhiliu; (391 pag.)WO2016/37578; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia