Synthetic Route of 18592-13-7 ,Some common heterocyclic compound, 18592-13-7, molecular formula is C5H5ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
In a 20 L reaction flask, compound SM1 (1000.0 g, 6.23 mol) was added to 5000 mL of acetic acid. Mechanical stirring was started and an ice bath was added. Sulfonyl chloride (1000 mL, 12.37 mol) was added dropwise keeping the temperature of the addition below 30 C. Canada completed at room temperature (20 ) reaction 6h, a large number of white solid precipitation. TLC trace compound SM1 point reaction disappeared (dichloromethane: methanol = 10: 1), the reaction was completed. The reaction mixture was suction filtered, and the resulting solid was air-dried for 12 hours at 60 C to give 5-chloro-6-chloromethyluracil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,18592-13-7, its application will become more common.
Reference:
Patent; Sinopharm Wholeheartedly Pharmaceutical Co., Ltd.; Wang Shujuan; Xu Hao; Kang Wei; (15 pag.)CN106892902; (2017); A;,
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