As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2927-71-1, name is 2,4-Dichloro-5-fluoropyrimidine, molecular formula is C4HCl2FN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 2,4-Dichloro-5-fluoropyrimidine
[0639] Synthesis of 2-chloro-5-fluoropyrimidine: [0640] To a stirred solution of 2, 4-dichloro-5-fluoropyrimidine (1 g, 5.98 mmol) in THF (10 mL) under argon atmosphere was added zinc (1.13 g, 17.96 mmol) at room temperature, heated to 70 C; then added acetic acid (0.36 mL, 5.98 mmol) and stirred for 6 h. The reaction was monitored by TLC; after completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated in vacuo to obtain the crude. The crude was purified through silica gel column chromatography using 10% EtOAc/ Hexanes to afford 2-chloro-5-fluoropyrimidine (280 mg, 35%) as colorless liquid. [0641] 1H-NMR (CDCls, 400 MHz): delta 8.52 (s, 2H); LC-MS: 90.01%; 133.1 (M++l); (column: X-Bridge C-18, 50 3.0 mm, 3.5 mupiiota); RT 1.29 min. 0.05% TFA (aq.): ACN; 0.8 mL/min); TLC: 10% EtOAc/ Hexanes (R/. 0.5).
With the rapid development of chemical substances, we look forward to future research findings about 2927-71-1.
Reference:
Patent; ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory; WO2013/142269; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia