Reference of 98136-42-6 ,Some common heterocyclic compound, 98136-42-6, molecular formula is C5H3Cl2N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 2,6-dichloropyrimidine-4-carboxamide (See EXAMPLE 2) (4.80 g, 25.0 mmol) in ACN (100 mL) was added (S)-3-aminopyrrolidin-2-one (Compound 40-18) (2.55 g, 25.54 mmol, Aldrich) and DIPEA (9.60 mL, 55.1 1 mmol). The mixture was heated at 50C overnight then concentrated in vacuo. The residue was purified by flash chromatography (SiO2, 20-60% acetone/hexanes) to give Compound 40-19 as a tan solid (4.79 g). Yield 75%. LC/MS: m/z= 256.2 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,98136-42-6, its application will become more common.
Reference:
Patent; PURDUE PHARMA L.P.; LOCKMAN, Jeffrey; NI, Chiyou; PARK, Jae Hyun; PARK, Minnie; SHAO, Bin; TAFESSE, Laykea; YAO, Jiangchao; YOUNGMAN, Mark, A.; WO2014/135955; (2014); A1;,
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