The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 933702-55-7, name is 2-Chloropyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Safety of 2-Chloropyrimidine-5-carbaldehyde
To a suspension of bromo(2,6-difluoro-3,5-dimethoxybenzyl)triphenyl- 5-phosphane (Example 513, step (d) (4.9g, 9.29 mmol) in anhydrous THF (lOmL) was added 60% NaH (0.5g, 12.67 mmol) portionwise at 0 C under argon atmosphere. The resultant reaction mixture was stirred at room temperature for 12h. A solution of 2-chloropyrimidine-5-carbaldehyde (1.2g, 8.45 mmol) in anhydrous THF (5mL) was added dropwise for 15min. and stirring was continued for overnight at room temperature. The reaction mixture was quenched with ice water and ethyl acetate. The aqueous layer was separated and extracted with ethyl acetate (3x50mL). The combined organic phase was washed with brine, dried over Na2S04, filtered and concentrated under vacuum. The residue was purified by trituration with ether to afford desired title compound (0.45g, 17.3%) LCMS: m/z = 313.2 (M+H)+.
With the rapid development of chemical substances, we look forward to future research findings about 933702-55-7.
Reference:
Patent; EISAI R & D MANAGEMENT CO., LTD.; REYNOLDS, Dominic; HAO, Ming-Hong; WANG, John; PRAJAPATI, Sundeep; SATOH, Takashi; SELVARAJ, Anand; (128 pag.)WO2016/164703; (2016); A1;,
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