The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4318-56-3, name is 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 4318-56-3
20.8 g of dichloromethane, 3.21 g of 6-chloro-3-methyluracil, 4.51 g of 2-cyanobenzyl bromide, and 5.16 g of DIPEA were successively added to the reaction flask with stirring, and the temperature was raised to reflux temperature. (40-45 C), HPLC sampling was run until 3-methyl-6-chlorouracil disappeared. After completion of the reaction, the reaction system was cooled to 20 ~ 25 C, dichloromethane was distilled off under reduced pressure, stirred with water after 1h was filtered, the filter cake was rinsed with water after adding ethanol, in the temperature 20 ~ 25 C, stirred for 1h After filtration, the filter cake is washed with ethanol andfinally dried under reduced pressure at a temperature of 60 to 70 C to obtain 5.28 g of a white crystalline solid 2-(6-chloro-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethyl)benzonitrile [hereinafter abbreviated as an intermediate], the yield was 95.8%.
With the rapid development of chemical substances, we look forward to future research findings about 4318-56-3.
Reference:
Patent; Changzhou Sunshine Pharmaceutical Co., Ltd.; Hu Guoyi; Hu Jinping; Gao Yongqing; Wang Yongcheng; Xi Xiaojin; (7 pag.)CN107954978; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia