Related Products of 89793-12-4, Adding some certain compound to certain chemical reactions, such as: 89793-12-4, name is Ethyl 2-chloropyrimidine-5-carboxylate,molecular formula is C7H7ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89793-12-4.
Ethyl 2-chloropyrimidine-5-carboxylate (7.0 Kgs), ethanol (60 Kgs), 2-Chloroaniline (9.5 Kgs, 2 eq) and acetic acid (3.7 Kgs, 1.6 eq) were charged to a reactor under inert atmosphere. The mixture was heated to reflux. After at least 5 hours the reaction was sampled for HPLC analysis (method TM-113.1016). When analysis indicated reaction completion, the mixture was cooled to 70 ± 5 °C and N,N-Diisopropylethylamine (DIPEA) was added. The reaction was then cooled to 20 ± 5°C and the mixture was stirred for an additional 2-6 hours. The resulting precipitate is filtered and washed with ethanol (2 x 6 Kgs) and heptane (24 Kgs). The cake is dried under reduced pressure at 50 ± 5 °C to a constant weight to produce 8.4 Kgs compound 1 1 (81 percent yield and 99.9percent purity.
According to the analysis of related databases, 89793-12-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ACETYLON PHARMACEUTICALS, INC.; MOORE, Nathan; MIN, Chengyin; (47 pag.)WO2018/85652; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia