Reference of 5305-45-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5305-45-3, name is 4,6-Dichloropyrimidine-5-carbonitrile, molecular formula is C5HCl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution OF 4, 6-DICHLORO-PYRIMIDINE-5-CARBONITRILE (254 mg, 1.47 mmol) and 2,5- difluoroaniline (190 mg, 1.47 mmol) in DMF (3 RNL) at 0C was added K2C03 (203 mg, 1.47 MMOL). The completion of the reaction was monitored by TLC (EtOAc: Hex =1 : 1, Rf= 0.90). After the reaction was complete, 4- (3-ISOPROPYL- [1, 2,4] oxadiazol-5-yl) -piperidine (340 mg, 1.47 mmol) and K2CO3 (406 mg, 2.94 mmol) were added at 0C. The reaction was warmed to rt and stirred for 30 min. The reaction was heated to 40C and maintained for 1 h. The reaction was cooled to rt, poured in to H20 (50 ML) and extracted with EtOAc (50 ML, two times). The EtOAc was dried over MgSO2 and concentrated under vacuum. The crude product was purified over SI02 (EtOAc: Hex = 1 : 1, Rf = 0.44) to afford the desired Compound B131 (465 mg; 71. 1 %). 1H-NMR (DMSO-D6) : 9.32 (1H, s), 8.19 (1H, s), 7. 40-7. 08 (3H, m), 4.54 (2H, m), 3. 48-3. 32 (4H, m), 3. 07-3. 01 (2H, m), 2. 18-2. 14 (2H, b), 1. 96-1. 86 (2H, m), 1.27 (6H, d) ppm. LCMS: 426.43.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5305-45-3, 4,6-Dichloropyrimidine-5-carbonitrile.
Reference:
Patent; ARENA PHARMACEUTICALS INC.; WO2004/65380; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia