Reference of 3740-92-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3740-92-9, name is 4,6-Dichloro-2-phenylpyrimidine, molecular formula is C10H6Cl2N2, molecular weight is 225.07, as common compound, the synthetic route is as follows.
A mixture of 80 (0.25g, 1.11mmol) and IPA (3ml) was stirred for a while and then 2M methylamine in THF (1.39ml, 2.78mmol) was added thereto at 0 °C. The resulting mixture was back to room temperature under stirring for overnight. The reaction was quenched by water and then the mixture was extracted by ethyl acetate (30ml x 3). The residue was purified by flash column over silica gel (ethyl acetate: n-Hexane = 1 :4, Rf = 0.18) to afford 84 (0.22g, 90.23percent) as a pale yellow solid. 1H-NMR (300MHz, CDCl3): delta 3.02 (d, J= 4.2 Hz, 3H), 5.09 (br, 1H), 6.26 (s, 1H), 7.42-7.46 (m, 3H), 8.35-8.37 (m, 2H).
The chemical industry reduces the impact on the environment during synthesis 3740-92-9, I believe this compound will play a more active role in future production and life.
Reference:
Patent; TAIPEI MEDICAL UNIVERSITY; YEN, Yun; LIOU, Jing-Ping; CHEN, Chun-Han; (70 pag.)WO2017/15400; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
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