Electric Literature of 3993-78-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3993-78-0, name is 2-Amino-4-chloropyrimidine. A new synthetic method of this compound is introduced below.
To a solution of 2-fluoro-5- (tetramethyl-l,3,2-dioxaborolan-2-yl)benzonitrile (1.71 g, 6.92 mmol) in dioxane (40 mL) was added 4-chloropyrimidin-2-amine (950 mg, 7.33 mmol), sodium carbonate solution (1.4 M in water, 10 mL, 14.00 mmol) and Pd(PCyg)2Ci2 (1.08 g, 1.47 mmol) at room temperature. The resulting mixture was stirred for 3 h at 100 C. When the reaction was done, the reaction mixture was concentrated under reduced pressure and the residue was purified by flash chromatography eluting with EtOAc in hexane (0 % to 100 % gradient) to yield 5-(2-aminopyrimidin-4-yl)-2- fluorobenzonitrile as an yellow solid (990 mg, 66 %). MS: m/z = 215.0 [M+H]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3993-78-0, its application will become more common.
Reference:
Patent; MERCK PATENT GMBH; KARRA, Srinivasa R.; XIAO, YuFang; SHERER, Brian A.; (380 pag.)WO2019/79373; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia