As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 115617-41-9, name is 4,5-Dichloro-6-ethylpyrimidine, molecular formula is C6H6Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 4,5-Dichloro-6-ethylpyrimidine
Step E 5-chloro-6-ethyl-N-[1-[4-(trimethylsilyl)phenyl]ethyl]-4-pyrimidinamine The product of Step D (17 g, 86 mole), 4,5-dichloro-6-ethylpyrimidine (15 g, 86 mole) and triethylamine (24 mL, 170 mole) were dissolved in toluene (65 mL). The reaction mixture was heated to reflux overnight and then cooled. Ether and water were added and the mixture was partitioned. The aqueous phase was extracted two times with ether and the combined organic phases were dried (MgSO4) and concentrated. The resultant solid was recrystallized from acetonitrile to give the title compound as a white solid (17 g, 60% yield), mp 79-80 C. 1 H NMR (CDCl3): delta 8.40 (s, 1H), 7.51, 7.36 (ABq, 4H), 5.60 (brd, 1H), 5.37 (q, 1H), 2.78 (q, 2H), 1.60 (d, 3H), 1.25 (t, 3H), 0.26 (s, 9H).
With the rapid development of chemical substances, we look forward to future research findings about 115617-41-9.
Reference:
Patent; E. I. Du Pont de Nemours and Company; US5378708; (1995); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia