Reference of 62802-38-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 62802-38-4, name is 5-Bromo-2-fluoropyrimidine. A new synthetic method of this compound is introduced below.
General procedure: 5-Bromo-2-fluoropyridine (0.5 mmol), an N-heterocyclic amine (1.0 mmol) and K2CO3 (1.0 mmol) were added to a 25-mL Schlenk tube, followed by addition of DMSO (2 mL). The reaction mixture was heated to 70 C for 24 h under air atmosphere. Then, the reaction mixture was added to brine (15 mL) and this mixture was extracted with CH2Cl2 (3 × 15 mL). The combined extracts were concentrated under reduced pressure and the product was isolated by flash chromatography on a silica gel (200-300 mesh) column.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62802-38-4, its application will become more common.
Reference:
Article; Tao, Sheng; Ji, Enhui; Shi, Lei; Liu, Ning; Xu, Liang; Dai, Bin; Synthesis; vol. 49; 23; (2017); p. 5120 – 5130;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia