With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.115617-41-9, name is 4,5-Dichloro-6-ethylpyrimidine, molecular formula is C6H6Cl2N2, molecular weight is 177.03, as common compound, the synthetic route is as follows.Recommanded Product: 115617-41-9
EXAMPLE 7 5-Chloro-6-ethyl-4-[cis-4-(isopropenyl)cyclohexylamino]pyrimidine (alternative synthesis) 1.6 g (0.009 mol) of 4,5-dichloro-6-ethylpyrimidine and 1.2 g (0.009 mol) of 4-isopropenylcyclohexylamine were stirred with 1.8 g (0.013 mol) of K2 CO3 in 10 ml of DMF at 80 C. for 6 hours. After cooling to room temperature, the mixture was placed in water and extracted with ether. The organic phase was washed with water, dried and filtered, and the filtrate was chromatographed on silica gel with petroleum ether/ethyl acetate 7:3 in order to separate the cis/trans isomers. The cis-cyclohexylamino derivative is eluted first (1.4 g, yellow oil) followed by the trans-cyclohexylamino derivative (0.6 g, yellow oil).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,115617-41-9, 4,5-Dichloro-6-ethylpyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; Hoechst-Schering AgrEvo GmbH; US5889012; (1999); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia