Adding a certain compound to certain chemical reactions, such as: 4983-28-2, 2-Chloro-5-hydroxypyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 4983-28-2, blongs to pyrimidines compound. SDS of cas: 4983-28-2
General procedure: A mixture of (2,6-difluoro-3,5-dimethoxy-phenyl)methyl methanesulfonate (440 mg, 1.56 mmol, 1.00 eq) , 2-chloropyrimidin-5-ol (203 mg, 1.56 mmol, 1.00 eq) and Cs2CO3 (762 mg, 2.34 mmol, 1.50 eq) in CH3CN (8.0 mL) was heated to reflux for 2 hours. LC-MS showed reaction was complete. The reaction mixture was quenched by addition of water (5 mL) at 0 C, and then extracted with ethyl acetate (10 mL × 2). The combined organic layers were washed with brine (10 mL), dried over Na2SO4, filtered and concentrated under reduced pressure to give a residue. The residue was purified by flash silica gel chromatography (ISCO;12 g SepaFlash Silica Flash Column, Eluent of 0~20% Ethyl acetate/Petroleum ethergradient 30 mL/min).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,4983-28-2, 2-Chloro-5-hydroxypyrimidine, and friends who are interested can also refer to it.
Reference:
Article; Wang, Yikai; Chen, Zhengxia; Dai, Meibi; Sun, Peipei; Wang, Chunqiu; Gao, Yang; Zhao, Haixia; Zeng, Wenqin; Shen, Liang; Mao, Weifeng; Wang, Tian; Hu, Guoping; Li, Jian; Chen, Shuhui; Long, Chaofeng; Chen, Xiaoxin; Liu, Junhua; Zhang, Yang; Bioorganic and Medicinal Chemistry Letters; vol. 27; 11; (2017); p. 2420 – 2423;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia