Synthetic Route of 153435-63-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 153435-63-3, name is 2-(Tributylstannyl)pyrimidine. A new synthetic method of this compound is introduced below.
A solution of the product from step 1 (1.74 g, 7.87 mmol), 2-20 (tributylstannyl)pyrimidine ( 4.36 g, 11.81 mmol), CsF ( 4.78 g, 31.5 mmol), and copper() iodide(0.450 g, 2.36 mmol) in DMF (16 mL) in a pressure vessel was sparged with nitrogen andtreated with Pd(PPh3)4 (0.455 g, 0.394 mmol). The mixture was sealed and heated at 120 ocovernight. The cooled reaction mixture was partitioned between EtOAc and water and filteredthrough celite. The organic layer was washed with saturated aqueous sodium bicarbonate and25 brine, dried over MgS04, filtered, and concentrated in vacuo. The residue was purified by silicagel chromatography (0-30% EtOAc in hexanes), to provide the title compound as a yellow solid.LRMS m/z (M+H) 221.2 found, 221.1 required.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,153435-63-3, 2-(Tributylstannyl)pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BESHORE, Douglas C.; KUDUK, Scott D.; LIVERTON, Nigel; LUO, Yunfu; MENG, Na; YU, Tingting; WO2015/18029; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia