In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 696-82-2, name is 2,4,6-Trifluoropyrimidine, the common compound, a new synthetic route is introduced below. Safety of 2,4,6-Trifluoropyrimidine
(Preparation by the process of the older German Patent Application P 39 00 471.6) 335.8 g (1.865 mol) of 30% strength sodium methylate (in methanol) were added to a mixture of 250 g (1.865 mol) of 2,4,6-trifluoropyrimidine and 1.4 1 of methanol at -20 C. over the course of 45 minutes, and the mixture was stirred at this temperature for a further 30 minutes. It was then allowed to warm to 25 C. and concentrated to about 1/5 of its volume. The resulting mixture was partitioned between diethyl ether and water, and then the organic phase was dried over magnesium sulfate and concentrated. Distillation (1.1 m column, 3 mm V-shaped packing) resulted in 141.6 g (52% of theory) of the title compound of boiling point 144-145 C. Distillation of the residue with a Normag head resulted in 114.4 g (42% of theory) of 4,6-difluoro-2-methoxypyrimidine of boiling point 157-161 C.
The synthetic route of 696-82-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Hamprecht; Gerhard; US5283332; (1994); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia