In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 115581-36-7, name is 2-Chloro-5-(methylthio)pyrimidine, the common compound, a new synthetic route is introduced below. SDS of cas: 115581-36-7
m-CPBA (545 mg, 3.15 mmol) was added to a stirred mixture of 2-chloro-5- (methylthio)pyrimidine (340 mg, 2.1 mmol) in DCM (20 mL). The resulting mixture was stirred for 10 minutes at rt, quenched by the addition of aqueous NaHCCh (10%, 40 mL), and extracted with DCM (3 x 50 mL). The combined organic layers was washed with brine (50 mL), dried over anhydrous NaiSCL, filtered, and concentrated under vacuum. The residue was purified by column chromatograph (EA in PE from 0% to 30%) to afford 2-chloro-5- (methylsulfonyl)pyrimidine (120 mg, 30% yield) as a white solid. LCMS (m/z) 193 (M+H)+, retention time: 0.56 min, LC/MS Method 9
The synthetic route of 115581-36-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; FOX, Ryan Michael; HARRIS, Philip Anthony; HOLENZ, Joerg; SEEFELD, Mark Andrew; ZHOU, Ding; (119 pag.)WO2019/130230; (2019); A1;,
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