Synthetic Route of 13223-25-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13223-25-1, name is 2-Chloro-4,6-dimethoxypyrimidine, molecular formula is C6H7ClN2O2, molecular weight is 174.59, as common compound, the synthetic route is as follows.
Example 7; Preparation of 2-hydroxymethyl-8-(4,6-dimethoxy-pyrimidin-2-yl)-l ,4-dioxa-8- azaspiro[4,5]decane (starting material for the preparation of Compound-7); 25 g of piperdone hydrochloride was slowly added in lots to 2g of TBAB and 67g of K2CO3 in 250 ml of acetonitrile at 50-60 (provide exact value), then 25 g of piperdone hydrochloride was slowly added in lots and the reaction mixture stirred for I hr. 29 g of 4,6-dimethoxy-2- chloropyrimidine was added slowly over a period of I hr and the reaction mixture was refluxed for 1 1 hours at 600C.The reaction mixture was neutralized with aq.NaOH solution and extracted with MDC, (methylene dichloride). Organic layer was distilled off to get l -(4-6-dimcthoy- pyrimidin-2-yl)-piperidin-4-one.45g of l -(4-6-dimethoxy-pyrimidin-2-yl)-piperidin-4-one. and 5.2 g of PTSA were stirred in toluene (400 ml) for half an hour. 21 g Glycerol ( 1.2 mole) was added drop wise and the reaction mixture was refluxed at 120 C for 7 hours. Toluene was removed to get the desired product with 85% yield.
The chemical industry reduces the impact on the environment during synthesis 13223-25-1, I believe this compound will play a more active role in future production and life.
Reference:
Patent; COUNCIL OF SCIENTIFIC &; INDUSTRIAL RESEARCH; DESHPANDE, Mukund, Vinayak; DESHPANDE, Sunita, Ranjan; SHIRAZI, Fazal; CHAUDHARY, Preeti, Madhukar; RAO, Nelavelli, Malleswara; MOHANTY, Baidyanath; SHARMA, Nageshwar, Nath; BACHHAWAT, Anand, Kumar; KALIANNAN, Ganesan; PAUL, Sanjoy; KUMAR, Raj; RAO, Bommena, Vittal; GAWALI, Bhimrao, Bodhanrao; REDDY, Vaddu, Venkata, Narayana; YADAV, Jhillu, Singh; WO2010/109299; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia