Application of 10320-42-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10320-42-0, name is 2-Chloro-5-nitropyrimidine. A new synthetic method of this compound is introduced below.
Dodecylmercaptan (24.77 mL) was dissolved in DMF (150 mL) and cooled to 0°C,60percent NaH (4.14 g) was added and stirred for 10 minutes, and2-chloro-5-nitropyrimidine (15 g) was added to the mixture, which was then stirred for1 hour at 0°C. Water was added to the reaction solution, and the resulting solid waswashed with water to obtain the object compound (26.01 g).NMR2: 0.88(3H, t, J=7.OHz), 1.18-1.38(16H, m), 1.38-1.50(2H, m), 1.64-1.76(2H, m),3.23(2H, t, =7.5Hz), 9.23(2H, s).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,10320-42-0, 2-Chloro-5-nitropyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; SHINOHARA, Tomoichi; IWATA, Shin; ARAI, Kenta; ITO, Nobuaki; SUZUKI, Masaki; (53 pag.)WO2018/221667; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia