Adding a certain compound to certain chemical reactions, such as: 6972-27-6, 6-Chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines
Method C: The stirred solution of solution of 6-chloro-l ,3-dimethylpyrimidine- 2,4(lH,3H)-dione (1 Kg) in ethanol (12 L) was added portion wise sodium hydrosulphide hydrate (1 kg) over a period of 1 h at 0 to 5C. After addition, the reaction mixture was stirred at 25 to 30C for 2 h. The reaction mixture was filtered and washed with ethanol (2 L). The filtrate was collected and concentrated under vacuum to obtain residue which was then dissolved in water (8 L). The aqueous solution was washed with dichloromethane (3 L) followed by petroleum ether (2 L). The aqueous layer was separated and was acidified using hydrochloric acid solution [4 L, cone, hydrochloric acid and water (1 : 1)]. The precipitated solid was filtered and washed with water followed by ethanol and dried to obtain the 0.8 Kg of the title compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6972-27-6, 6-Chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.
Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; KADAM, Suresh Mahadev; THOMAS, Abraham; SINHA, Sukumar; KUMAR, Sukeerthi; KANSAGRA, Bipin Parsottam; GAVHANE, Sachin; KHANDAGALE, Sandeep Bandu; PAWASE, Shailesh; PATIL, Jayant Prakashrao; BHADANE, Shailendra; MISHRA, Bhavna; DWIVEDI, Rajesh; WO2013/183035; (2013); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia