Synthetic Route of 5177-27-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5177-27-5 as follows.
To 2,4-dichloro-pyrimidin-5-ylamine (3.03 g, 18.1 mmol)In n-BuOH (40 mL)(1S,2S)-2-Amino-cyclopentanol hydrochloride (2.50 g, 17.2 mmol) was added to the stirred suspensionAnd DIEA (9.20 mL, 51.8 mmol).The mixture was stirred at 130 C for 4 h.Then the reaction mixture under reduced pressure and EtOAc was concentrated and the crude product was triturated in the heptane and filtered to yield a solid BT-1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5177-27-5, its application will become more common.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BAKONYI,JOHANNA; BRUNETTE,STEVEN RICHARD; COLLIN,DELPHINE; HUGHES,ROBERT OWEN; LI,XIANG; LIANG,SHUANG; SIBLEY,ROBERT; TURNER,MICHAEL ROBERT; WU,LIFEN; ZHANG,QIANG; (169 pag.)TW2018/38997; (2018); A;,
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