Synthetic Route of 111196-81-7, Adding some certain compound to certain chemical reactions, such as: 111196-81-7, name is 2-Chloro-5-ethylpyrimidine,molecular formula is C6H7ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 111196-81-7.
Step B: Preparation of 4-((lr,4r)-4-((l-(5-Ethylpyrimidin-2-yl)piperidin-4- yl)methoxy)cyclohexyl)nicotinonitrile (Compound 58).; A mixture of 4-((lr,4r)-4-(piperidin-4-ylmethoxy)cyclohexyl)nicotinonitriledihydrochloride (26.5 mg, 71.17 muetaiotaomicron), 2-chloro-5-ethylpyrimidine (43 mu, 0.354 mmol), and potassium carbonate (50 mg, 0.362 mmol) in 1 ml iPrOH was heated under microwave irradiation at 100C for 3 h. Mixture was extracted with water and CH2C12. Organic phases were dried over MgS04, filtered, and concentrated. Residue was purified by biotage CC (Si02, hexane/AcOEt gradient). Fractions containing product were concentrated and residue was re- purified by HPLC (CH3CN/H20 gradient + 0.1% TFA). Fractions containing product were partly concentrated and residue was extracted with 1 M NaOH and CH2C12. Organic phases were dried over MgS04, filtered, and concentrated to give 4-((lr,4r)-4-((l-(5-ethylpyrimidin-2- yl)piperidin-4-yl)methoxy)cyclohexyl)nicotinonitrile (22.1 mg, 54.50 muetaiotaomicron, 76.6 %) as a white solid. Exact mass calculated for C24H3iN50: 405.25, found: LCMS m/z = 406.4 (M+H+); lU NMR (400 MHz, CDC13) delta ppm 1.19-1.29 (m, 5H), 1.41-1.62 (m, 4H), 1.83-1.89 (m, 3H), 1.98- 2.04 (m, 2H), 2.20-2.26 (m, 2H), 2.47 (q, = 7.6, 2H), 2.86-2.97 (m, 3H), 3.27-3.35 (m, 1H), 3.38 (d, = 6.3 Hz, 2H), 4.71-4.77 (m, 2H), 7.28 (d, = 5.3 Hz, 1H), 8.18 (s, 2H), 8.71 (d, = 5.3 Hz, 1H), 8.82 (s, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 111196-81-7, 2-Chloro-5-ethylpyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; JONES, Robert M.; HAN, Sangdon; LEHMANN, Juerg; THORESEN, Lars; WO2012/135570; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia