Adding a certain compound to certain chemical reactions, such as: 111196-81-7, 2-Chloro-5-ethylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 111196-81-7, blongs to pyrimidines compound. name: 2-Chloro-5-ethylpyrimidine
To a solution of5-[4-(methanesulfonyl)phenyl]-1-(piperidin-4-yl)-1H-pyrazolo[3,4-c]pyridine hydrochloride (0.153 mmol) in dimethylsulfoxide (DMSO) (1.5 ml) were added 2-chloro-5-ethylpyrimidine (44 mg, 0.309mmol) and Cs2CO3 (249 mg, 0.734 mmol). The mixture wasstirred at 180 C under microwaveirradiation for 20 min. The reaction was diluted with water andextracted with ethyl acetate. The combined organic layers were dried overanhydrous Mg2SO4 and reduced under pressure. The residuewas purified by silica gel column chromatography (0-50% EtOAc in hexanes) toafford 20 as a colorless solid (44mg, 62% yield).1H NMR (300 MHz, CDCl3): delta ppm1.22 (t, J = 7.5 Hz, 3 H), 2.14 -2.25 (m, 2 H), 2.26 – 2.45 (m, 2 H), 2.50 (q, J = 7.5 Hz, 2 H), 3.10 (s, 3 H), 3.13 – 3.25 (m, 2 H), 4.81 – 4.93(m, 1 H), 4.93 – 5.03 (m, 2 H), 8.02 – 8.08 (m, 2 H), 8.11 – 8.14 (m, 2 H),8.20 – 8.27 (m, 4 H), 9.14 (s, 1 H).MS ESI/APCI Dual m/z: 463 [M+1]+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111196-81-7, its application will become more common.
Reference:
Article; Matsuda, Daisuke; Kobashi, Yohei; Mikami, Ayako; Kawamura, Madoka; Shiozawa, Fumiyasu; Kawabe, Kenichi; Hamada, Makoto; Oda, Koji; Nishimoto, Shinichi; Kimura, Kayo; Miyoshi, Masako; Takayama, Noriko; Kakinuma, Hiroyuki; Ohtake, Norikazu; Bioorganic and Medicinal Chemistry Letters; vol. 26; 15; (2016); p. 3441 – 3446;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia