Electric Literature of 29274-22-4 ,Some common heterocyclic compound, 29274-22-4, molecular formula is C6H5N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of pyrazolo[l ,5-a]pyrimidin-5-ol (17.0 g, 126 mmol) inPOCI3 (100 mL) was heated at reflux for 3 hours. After cooling, the reaction was concentrated under vacuum. To the residue was added dichloromethane. The organic phase was carefully washed with saturated aqueous NaHC03 solution, dried and concentrated. The crude product was purified by passing through a short silica gel pad eluting with 50%> EtOAc in hexane to give 5-chloropyrazolo[l ,5-a]pyrimidine (13.1 g, 68%>).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,29274-22-4, its application will become more common.
Reference:
Patent; ARRAY BIOPHARMA INC.; ANDREWS, Steven W.; CONDROSKI, Kevin Ronald; DE MEESE, Lisa A.; FELL, Jay Bradford; FISCHER, John P.; LE HUEROU, Yvan; JOSEY, John A.; KOCH, Kevin; MIKNIS, Gregory F.; RODRIGUEZ, Martha E.; TOPALOV, George T.; WALLACE, Eli M.; XU, Rui; WO2011/29027; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
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