Some scientific research about 4,5,6-Trifluoropyrimidine

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 17573-78-3, name is 4,5,6-Trifluoropyrimidine. A new synthetic method of this compound is introduced below., name: 4,5,6-Trifluoropyrimidine

Example 1-3; 0.5 g of 4,5,6-trifluoropyrimidine, 0.38 g of 2-pentyn-l-ol and 0.62 ml of triethylamine were added to 1 ml EPO of toluene, then the mixture was stirred at room temperature for 1 hour. Then the reaction mixture was subjected to silica gel column chromatography to obtain 0.53 g of 4,5-difluoro-6-(2-pentynyloxy)pyrimidine. 1H-NMR: 1.15(t,3H), 2.26(qt,2H), 5. ll(t,2H) , 8.26(s,lH)

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Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2006/51891; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia