Adding a certain compound to certain chemical reactions, such as: 83410-15-5, 4-Chloro-5-iodo-6-methylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 4-Chloro-5-iodo-6-methylpyrimidine, blongs to pyrimidines compound. Recommanded Product: 4-Chloro-5-iodo-6-methylpyrimidine
A mixture of 2.38 g (9.73 mmol) A-3, 1.55 g (13.1 mmol) D-10, 53 mg (0.28 mmol) CuI, 0.25 g (0.94 mmol) triphenylphosphine, 0.20 g (0.28 mmol) bis(triphenylphosphine)-palladium(II) chloride and 15.6 mL (112 mmol) triethylamine in 15 mL dry THF is stirred under argon atmosphere at 85 C. for 1 h. The reaction mixture is cooled to RT and 100 mL DCM and 100 mL water are added. The phases are separated and the organic phase is washed with water, dried over MgSO4 and concentrated under reduced pressure. The residual product is purified by NP chromatography (silica gel, 2-15% MeOH containing 0.1% NH3 in DCM). Yield: 0.74 g (32%).
The synthetic route of 83410-15-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WUNBERG, Tobias; KRAEMER, Oliver; van der VEEN, Lars; US2013/23533; (2013); A1;,
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